Pharmacodynamic Target Attainment for Meropenem and Piperacillin/Tazobactam Using a PK/PD-based Dosing Calculator in Critically Ill Patients
نویسندگان
چکیده
957. Pharmacodynamic Target Attainment for Meropenem and Piperacillin/ Tazobactam Using a PK/PD-based Dosing Calculator in Critically Ill Patients Emily Heil, PharmD, BCPS-AQ ID; David P. Nicolau, PharmD, FCCP, FIDSA; Gwen Robinson, MPH; Andras Farkas, PharmD; Kerri Thom, MD, MS; Pharmacy Practice and Science, University of Maryland School of Pharmacy, Baltimore, MD; Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, Connecticut; University of Maryland School of Medicine, Baltimore, MD; Mount Sinai West Hospital, New York, New York; Computer Simulation Studies, Optimum Dosing Strategies, Bloomingdale, New Jersey; University of Maryland, Baltimore, Baltimore, MD
منابع مشابه
Monte Carlo simulations: maximizing antibiotic pharmacokinetic data to optimize clinical practice for critically ill patients.
Infections in critically ill patients continue to result in unacceptably high morbidity and mortality. Although few data exist for correlating antibiotic exposure with outcome, antibiotic dosing is likely to be highly important for maximizing resolution of infection in many patients. The practical and financial difficulties of performing pharmacokinetic (PK) studies in critically ill patients m...
متن کاملA Novel Antimicrobial Stewardship Program-Guided Procalcitonin Initiative for Emergency Department Diagnosis of Bacterial Pneumonia in New York City
957. Pharmacodynamic Target Attainment for Meropenem and Piperacillin/ Tazobactam Using a PK/PD-based Dosing Calculator in Critically Ill Patients Emily Heil, PharmD, BCPS-AQ ID; David P. Nicolau, PharmD, FCCP, FIDSA; Gwen Robinson, MPH; Andras Farkas, PharmD; Kerri Thom, MD, MS; Pharmacy Practice and Science, University of Maryland School of Pharmacy, Baltimore, MD; Center for Anti-Infective R...
متن کاملAre standard doses of piperacillin sufficient for critically ill patients with augmented creatinine clearance?
INTRODUCTION The aim of this study was to explore the impact of augmented creatinine clearance and differing minimum inhibitory concentrations (MIC) on piperacillin pharmacokinetic/pharmacodynamic (PK/PD) target attainment (time above MIC (fT>MIC)) in critically ill patients with sepsis receiving intermittent dosing. METHODS To be eligible for enrolment, critically ill patients with sepsis ha...
متن کاملMeropenem and piperacillin/tazobactam prescribing in critically ill patients: does augmented renal clearance affect pharmacokinetic/pharmacodynamic target attainment when extended infusions are used?
BACKGROUND Correct antibiotic dosing remains a challenge for the clinician. The aim of this study was to assess the influence of augmented renal clearance on pharmacokinetic/pharmacodynamic target attainment in critically ill patients receiving meropenem or piperacillin/tazobactam, administered as an extended infusion. METHODS This was a prospective, observational, pharmacokinetic study execu...
متن کاملOptimizing pharmacodynamic target attainment using the MYSTIC antibiogram: data collected in North America in 2002.
The OPTAMA Program is intended to examine typical antimicrobial regimens used in the treatment of common nosocomial pathogens and the likelihood of these regimens attaining appropriate pharmacodynamic exposure in different parts of the world. A 5,000-subject Monte Carlo simulation was used to estimate pharmacodynamic target attainment for meropenem, imipenem, ceftazidime, cefepime, piperacillin...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 4 شماره
صفحات -
تاریخ انتشار 2017